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Release of presynaptic glutamate and activation of postsynaptic glutamate receptors on the postsynaptic neuron stimulate influx of Na + and Ca 2+ ions into the postsynaptic neuron, which contributes to depolarization and action potentials ( Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000

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Additional risk factors include having your gut operated on, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders