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While p-SIRT7 levels were reduced by LiCl-mediated GSK3 inactivation and increased by AMPK activation under low-glucose conditions, the phosphorylation levels of SIRT7-2A and T263A mutants were not affected by these treatments (Fig

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Together, these findings indicate that higher-order cognition, spatial learning, and memory may be differentially affected by high exposure to jet fuels, and it is possible that effects may differ based on fuel type and cognitive domain