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One of the mechanisms by which fungi participate in cancer development and progression is by inducing alterations in the immune response

The expression profile of genes monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF), tumor necrosis factor receptor type 1 (TNFR1), transforming growth factor-beta-1 (TGF1), collagen type I alpha 1 chain (Col1,) actin alpha 2 smooth muscle (SMA), tissue inhibitor of metalloproteinases 1 (Timp1), and haptoglobin (Hp) associated with non-alcoholic fatty liver disease (NAFLD) were elevated in the livers of mice fed an HFD for 16 weeks compared with those from mice fed the control diet (Fig

In addition to neutralizing endogenously generated reactive oxygen and nitrogen species, GSH is known to facilitate the plasma membrane transport of toxins by at least four different mechanisms, the most important of which is the formation of glutathione S-conjugates

doi: 10.1074/jbc.M111.314062 28 YangWLiangZWenCJiangXWangL