Each cage was identified with the date, the number of the study, group, dose, number, and sex of each animal
Preclinical studies showed no adverse effects across several organ systems including liver, spleen, lung, kidney, brain, thymus, prostate, and ovaries in studies up to 6 weeks
Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)
No content here should be interpreted as a treatment recommendation or as a substitute for qualified clinical care