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Expression of p63 and Axin2 then decreased at 5 to 7 d post-infection, regardless of whether the cells were incubated in 50% or 5% CM at day 3 post-infection, showing that either extended culture or lower CM percentage can reduce Wnt signalling

Vitamin D or B12 may be part of the picture, but your provider will want to look more broadly, and blood work is often part of that evaluation

Moreover, VK2 suppresses the MAPK/NF-B axis, resulting in decreased production of MMP3 and MMP13, while enhancing the synthesis of type II collagen and proteoglycans, so collectively mitigating ECM breakdown [114]

If you suspect that you may have a deficiency, a doctor can test your blood levels to determine if a supplement could be beneficial