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Also, xCT is mainly responsible for cystine/glutamate exchange and highly specific to Cys and glutamate ( c is inhibited, the production of GSH is decreased and the level of ROS and lipid peroxidation is increased, thereby leading to the occurrence of ferroptosis ( Glutathione exists in two formsreduced (GSH) and oxidized (GSSG)and the ratio of the two forms (GSSG/GSH) indicates the degree of oxidative stress in cells (Figure 3)

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Whilst this study primarily focused on metformin-mediated effects in tumour cells, increasing evidence implicates a role for metformin in the modulation of immune cells, with metformin demonstrated to modulate macrophage polarisation (71) and the infiltration and function of T-cells (72, 73)

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