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Moosbrugger-Martinz V, Leprince C, Mchin M-C, Simon M, Blunder S, Gruber R, Dubrac S (2022) Revisiting the roles of filaggrin in atopic dermatitis

The elevation in Nrf2 at day 0 may have been in response to increased oxidative stress (evidenced by elevated H 2 O 2 and MDA concentrations) that was also present at day 0 to activate enzymes like SOD

Thus, maternal separation can lead to the offspring having lower voluntary food intake and a preference for foods low in carbohydrates (Penke et al., 2001), while social isolation in previously maternally separated rats elevates food intake and weight gain (Ryu et al., 2009)