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Metabolic imaging using hyperpolarized 13 C-pyruvate to assess sensitivity to the B-raf inhibitor vemurafenib in melanoma cells and xenografts

However, neither COX-2 nor 5-LOX was expressed in the brain tissue cells or blood vessels of BALB/c mice

A compound interaction and pharmacokinetic analysis did not indicate that CYP2C9 and CYP2C19 were inhibited

In conclusion, our findings strongly suggest that while not all benefits of CR require fasting, fasting plays a critical role in CR-induced improvements in AD pathology