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In addition, IL-6 induces the overexpression and nuclear translocation of transcription factor STAT-3 through trans- signaling, which results in T-cell resistance to apoptosis by inducing the expression of the anti-apoptotic factors bcl-2 and bcl-xl

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Additionally, the health issue exposed by the consumption of e-cigarettes is less as compared to the consumption of conventional cigarettes and is leading to increased adoption of e-cigarettes in the Arabian countries