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It is known that endogenous levels of GHK peptide naturally decline with age, from roughly 200 ng/ml at age 20 to 80 ng/ml at age 60 [3], and studies have shown that GHK-Cu can reset gene expression of human cells to a healthier state, which has led to breakthroughs in tissue regeneration and wound healing [4, 5, 6]

On induction with interferon- (IFN-), the constitutive 1, 2 and 5 subunits of 20S proteasome are replaced by catalytically active inducible 1i (PSMB9), 2i (PSMB10) and 5i (PSMB8) subunits referred as the immunoproteasome 24,25

The road to inhibition of these factors has three steps: Restore, Maintain, and Advance