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- Use 1-2 times/day (preferably in the evening), at the same time, should combine physical exfoliation 2-3 times/week, avoid strong chemical exfoliants, which can cause skin irritation

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At present, regulatory agencies like the FDA and the European Commission evaluate CQDs on a case-by-case basis, irrespective of a specific regulatory procedure as these nanomaterials do not fit neatly within existing classifications for pharmaceuticals, biologics, or medical devices [172]