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Regarding the inflammatory component in neuronal disorders, ALA and DHLA inhibit inflammasomes in neural tissues by decreasing pro-inflammatory mediators, such as interleukin-2 (IL-2), IFN-, and TNF-, increasing anti-inflammatory cytokines such as interleukin-10 (IL-10), and regulating the transcription of nuclear factors Nrf2 and NF-B in physiological processes

This designation allows the use of research chemicals strictly for laboratory experimentation only

Across both trials, the reported safety profile was described as consistent with prior experience for the compound class, with gastrointestinal adverse events predominating

Surguchov A