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Ibuprofen, meanwhile, can cause dyspepsia, gastric erosion, and peptic ulceration, particularly with prolonged use or in patients with risk factors such as advanced age, previous peptic ulcer disease, or concurrent use of corticosteroids or anticoagulants

The concern stems from its activation of the VEGFR2 pathway and FAK-paxillin signaling, which drive angiogenesis and are dysregulated in 50% of human cancers (ovarian cancer, melanoma, and colon adenocarcinoma)

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An emergency room study showed that while IV fluids alone didn't reduce time to wake up in acute alcohol intoxication cases, they did improve overall hydration status and how patients felt