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IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo

Predictive neuroimaging, such as magnetic resonance imaging-based MRC/MitoD mapping, now stratifies patients by metabolic vulnerability: High MRC in the putamen predicts lactate-driven cognitive fatigue, as validated in 45 stroke patients [49]

it should only ever be considered under direct medical supervision after appropriate clearance