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These challenges, which could cause a decrease in brain creatine, could be acute (e.g., sleep deprivation, intense exercise) or chronic (e.g., aging, traumatic brain injury, depression, Alzheimers disease, creatine synthesis enzyme deficiencies).[ref] Another study found that Creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (6676 years).[ref] Creatine and the Methylation Cycle: The methylation cycle is a cellular process for producing methyl groups (a carbon + 3 hydrogen atoms) for use in many types of biochemical reactions

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doi: 10.1016/j.etap.2016.05.020 45 MinasACamargoMAlvesMGBertollaRP