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Heavy alcohol use in patients infected with hepatitis C accelerates the rate of liver damage and increases the risk of cirrhosis

Additionally, high levels of expression of Nrf2, ABCC1, ABCC3 plus NAD(P)H dehydrogenase quinone-1 in breast tumors of patients at the time of diagnosis were prognostic of poor survival after tamoxifen therapy

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81 In females, Vitamin A, carotenoids, resveratrol, and quercetin have been demonstrated to enhance the activity of endogenous antioxidant enzymes (SOD, CAT, GPx, and GR) in the ovary by stimulating the Nrf2 signaling pathway to increase the expression of these enzymes