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Function Cofactor for methionine synthase Methylcobalamin is required for the function of the folate-dependent enzyme, methionine synthase

Thus exhibiting a pleiotropic anti-glioma phenomenon in both in vitro and in vivo systems by inhibiting proteins involved in cell survival [(Nuclear factor-kappa B (NFB), Phospho-Akt (p-Akt), B-cell lymphoma-extra-large (Bcl-xl) and Heat shock protein 70 (HSP70)], proliferation (cyclin D1), angiogenesis [Vascular endothelial growth factor (VEGF)], invasion [Matrix metallopeptidases (MMPs), Neural cell adhesion molecule (NCAM) and polysialylated neuronal cell adhesion molecule (PSA-NCAM)] of glioma cells [114]

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