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Glutathione works to protect cells mitochondria by eliminating free radicals

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However, neither BAL fluid nor intracellular GSH, GSSG, and GSH:GSSG correlated with BAL eosinophils or any other inflammatory cell, suggesting eosinophilia plays a lesser role in contributing to higher extracellular/BAL fluid GSSG than epithelial cells do (Supplemental Tables 3 and 4)

In vivo , ICA treatment partially restored type II collagen and GPX4 expression, reduced ECM degradation in chondrocytes, and restrained chondrocyte ferroptosis, alleviating OA joint damage