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Mn predominantly enters the CNS through the faster extracellular route, where it is carried paracellularly via bulk flow to the CSF and subsequently diffuses into the brain ( via metal transporters ( 54 Mn uptake (Thompson et al., 2007) (Figure 2)

He was told that he was not enrolled in a clinical trial and was informed of possible side effects of the treatments, including that his current condition might worsen

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