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The problem is that TNF-alpha is so broadly important to immune function that blocking it entirely creates its own complications

Potter, Modulation of human glutathione S-transferases by botanically defined vegetable diets, cancer epidemiol biomarkers prev , vol

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Inhibition of AR has been shown to suppress the expression of Th2 cytokines and reduce airway hyperresponsiveness, IgE levels, and eosinophil infiltration in animal models of asthma, which suggests its potential as a therapeutic target [136]