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4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

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Given the clinicopathological significance of SLC1A5 201 and the observation that the level of the SLC1A5 variant is negatively correlated with prognosis in several cancer types 16 , targeting the SLC1A5 variant is a promising strategy to starve cancer cells and induce antitumor effects

Model Systems and Biological Factors The type of model system being used whether its an in vitro setup or an animal model significantly impacts dosing