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The antioxidant system in body can reduce the levels of O 2 and HO, decreasing OH production and inhibiting NETosis [245]

10.1016/j.immuni.2014.09.008 26 RossS.EikelboomJ.AnandS

Using synergistic drug combination prediction algorithms, such as multi-objective evolutionary algorithms and random search algorithms, synergistic drug combinations can be rapidly screened from large-scale drug combination spaces (Zinner et al., 2009)

With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism