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The clone with an R121S substitution showed the best activity and was named G1 (Supplementary Fig

However, cases were assigned as non-overdose by an expert committee if there was no history of overdose and a non-toxic plasma paracetamol concentration (PPC), meaning that some of these cases may in fact have been concealed overdoses if a history of overdose was not given and enough time had elapsed for PPC to become undetectable [26]