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[8] In addition, drugs that affect blood cell production, such as certain chemotherapy agents or some HIV medications, may blunt the benefits of vitamin B or alter blood counts

Homocysteine and cardiovascular disease Observational studies indicate that even moderately elevated blood concentrations of homocysteine raise the risk of cardiovascular disease (CVD), although randomized controlled trials of homocysteine-lowering therapy have generally not translated to reductions in adverse cardiovascular outcomes (26, 27)