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These data indicate that the dietary antioxidants vitamin D and vitamin E play a key regulatory role in the pathways of endogenous GSH synthesis

This chapter summarizes their roles in stress responses as antioxidant enzymes, in determining the redox status of cells, and emphasizes their connection to redox signaling mechanisms

Damage to the mitochondrial electron transport chain increases ROS leakage, further amplifying oxidative stress ( Lipid peroxidation forms a feedback loop that exacerbates ferroptosis and ARDS progression