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If patients experience symptoms consistent with Torsades de Pointes, or other arrhythmias (e.g., syncope, presyncope, dizziness, or palpitations), obtain a cardiac evaluation and discontinue clozapine

In addition, the major metabolites and their derivatives, such as l-Glutamic acid, pyroglutamic acid, pyroglutamylglycine, d-pantothenoyl-cysteine, and the activities of some key enzymes involved in GSH metabolism pathway, such as glutamate cysteine ligase (GCL), glutathione synthetase (GS) and glutathione S-transferase (GST), were all significantly downregulated by CS exposure, while these alterations were prominently restored by AZI treatment (Fig