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In each of the 3 survey categories (appearance, symptoms, and psychosocial impact), most patients indicated that they were not bothered by their scar

According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects

Methotrexate and 5-flurouracil are antimetabolites that are widely used for the treatment of cancers

PMID: 20805969