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Consistent with this, cofilin KO mice showed altered spine morphology and synaptic plasticity (Rust et al., 2010

A similar strategy was used by DallAcqua and colleagues to generate human IgG1 variants with increased affinity for both mouse and human FcRn [100]

However, if the goal is to study systemic effectslike tendon repair, muscle recovery, or neuroprotectiona higher dose might be necessary to ensure enough of the compound survives the digestive gauntlet and reaches the bloodstream to circulate throughout the body

The comparison between these two healing peptides is covered thoroughly in the BPC-157 vs TB-500 analysis