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Therapeutic strategies aimed at preventing neuronal degeneration and vision loss have focused on modulating neurotrophic and angiogenic signaling pathways as well as using iPS cell-derived retinal tissues to replace damaged RPE cells/photoreceptors, stabilizing retinal structure and visual function 41,42,43,44

When protein crystallographers first observed missing electron density is not a single, documented event with a specific date because it is inherent to the process of X-ray crystallography, especially when working with biological macromolecules

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