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Limitations of RCTs presented in Table 2 and Table 3 The side effects reported at the end of a clinical trial may be partially distorted due to gastrointestinal problems if the study is stopped too early [127]

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however, senescent cells infamously secrete high levels of pro-inflammatory cytokines, chemokines, and extracellular matrix-degrading proteins that negatively impact the extracellular environment and induce spread of senescence to non-senescent cells (29-32)