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When antibiotics, particularly sulphur drugs, are used for extended periods, the normal synthesis of Folic acid in the gut will be reduced and the requirements for Folic Acid are increased.

These labile copper pools are important for the assembly of iron-sulfur (FeS) clusters, which are directly linked to mitochondrial function 117,118

To determine the diastereomeric ratio values, the sample was analyzed by chiral analytical HPLC with a CHIRALPAK IA-3 column (150 4.6 mm, 3 m) at room temperature (flow rate 1 ml min 1 , 40% acetonitrile in H 2 O with 0.1% trifluoroacetic acid)

100 Asn also has a key role in hematological malignancies