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Interestingly, some metabolites such as malate, -ketoglutarate, ornithine, glutamate, ornithine, phenylalanine, tryptophan, tyrosine, leucine, and histidine had higher percentage 13 C-labelling in three or more carbon atoms (M+ 3) in the gdh3 / gdh3 mutant compared to wild-type cells grown in 30% U- 13 C 5 proline medium

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Finally, Phase 4 trials monitor the long-term safety and efficacy of a therapy after its approval

In summary, the development of pharmacological agents that promote itaconate production could potentially mitigate pathological inflammatory responses and prevent severe lung injury associated with TB progression