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Moreover, in agreement with the critical role of the capsule for meningococcal intracellular survival (Spinosa et al., 2007), siaD deletion in the MC58 strain led to an increase in adhesion to Calu3 LLI but to a strong reduction in intracellular bacteria and in transcellular crossing (Sutherland et al., 2010)

Secondly, it has been indicated that high doses or long-term NAM reduces the methyl group availability and cellular methylation potential via promoting the methyl sink in the form of 1MNA

a , Immunoblot analysis of control (shCtrl) and GDH1 knockdown (shGDH1) cancer cell lines