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Since figuring out how much nicotine you get per puff is not an exact science, it's best to just do what you want

The following medications help manage withdrawal symptoms: Methadone : A long-acting opioid agonist that prevents withdrawal symptoms and reduces cravings in individuals detoxing from opioids

2010, Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. This neurotransmitter release results in feelings of pleasure and reward, reinforcing the addictive nature of tobacco use