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Side-by-side comparison between a recombinant WT IgG1 Fc fragment and a recombinant analog of efgartigimod (IgG1 Fc fragment with MST/HN) revealed that the binding of MST/HN IgG1 Fc at pH 7.4 (KD of ~1220 nM) is approximately 5-fold weaker than that exhibited by WT IgG1 Fc at pH 6.0 (KD of ~272 nM) [225]