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Pathophysiology of fatty liver disease The early phase of fatty liver disease is typified by an accumulation of lipids, marked by the excessive deposition of TG within hepatocytes, primarily in the form of lipid droplets (Scorletti and Carr 2022)

Taking high doses of energy-synthesizing B-vitamins and CoQ10 late in the evening may lead to overstimulation and interfere with sleep architecture, which is already frequently disrupted in patients with chronic fatigue syndromes