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Most young people do not consider the long-term health consequences associated with tobacco use when they start smoking

Chronic exposure of mice to SHS (90% side stream, 10% mainstream smoke x 2.8 h/day x 7 days/wk x 10.4 mos) induces dark, shrunken cells, hippocampal thinning, and the presence of activated astrocytes and prominent 8-oxoG staining in the prefrontal cortex (PFC) and hippocampus (HIPP) (Raber et al., 2021

While propylene glycol alone did not alter ICSS thresholds, co-administration of propylene glycol and nicotine decreased the aversion-associated increase in ICSS thresholds, which was induced by the high dose of nicotine alone (78)