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In studies reporting event counts, ALC arm events were mainly categorized as gastrointestinal (GI) and central nervous system (CNS), with other systems (skin/subcutaneous, urinary, cardiovascular, endocrine/metabolic, reproductive) reported infrequently

49 Moreover, it appears that ketamine or its metabolites induces microvascular changes in the bladder and possibly the kidney, causing an autoimmune reaction against the bladder urothelium and submucosa