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Regulation of metabolic pathways by supplementation of structural analogs of metabolites (antimetabolites) inhibiting metabolic reactions is used to search for limiting steps of biosynthesis and ways to overcome them, including development of strain antimetabolite resistance (Schmidt et al., 1996
H4R plays a key protective antibacterial role in innate immune signaling As both adaptive T-cell and innate immune responses likely contribute to inflammation in colitis, we wondered what the effect of losing both adaptive immunity and this novel innate immune H4R-mediated pathway would be on mice undergoing experimental colitis
SSR103800 demonstrated efficacy in improving episodic memory and object recognition in rodent paradigms, highlighting its relevance to cognitive symptom domains (Boulay et al
doi: 10.1016/S0140-6736(63)91500-9
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