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Over time, the brain adapts by: Reducing natural dopamine production Requiring higher doses of nicotine to feel the same effects Increasing cravings and irritability without nicotine The National Institute on Drug Abuse (NIDA) reports that nicotine produces addiction-related brain changes comparable to other highly addictive substances, helping explain why quitting can feel difficult even after relatively short-term use

The aims of the study were to test the following hypotheses: a) rates of smoking increase with increasing level of non-specific psychological distress after adjusting for socio-demographic factors including education, income and marital status b) among adults who smoke, rates of wanting to quit smoking, attempting to quit smoking and using smoking cessation aids do not vary by level of non-specific psychological distress c) among adults who smoke, rates of quitting smoking decrease with increasing level of non-specific psychological distress