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Historically, from the 1970s, the tobacco industry has conducted pharmacological studies on several nicotine analogs, to understand their pharmacological effects and determine their potential to replace nicotine in products and also to circumvent any foreseeable regulations on nicotine 14

The best menthol products use natural mint (peppermint or spearmint species) rather than synthetic menthol, which is one of the differentiators between premium and budget menthol cigarettes

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These statements suggest that nixotine has potentially nicotine-like pharmacological and behavioral actions