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It did not affect CDNB concentration measured in the outflow perfusate collected from the cardiac atrium (means +/- SEM of 119 +/- 8 M and 168 +/- 34 M in vehicle- and DMF-treated animals, respectively), ruling out the possibility that the decreased concentration of toxicant in CSF following DMF treatment resulted from a decreased xenobiotic concentration in the choroidal vascular system in our experimental conditions