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According to the pathogenicity criteria from the American College of Medical Genetics and Genomics, the variants can be classified as pathogenic, likely pathogenic, benign, likely benign, or VUS [85], based on criteria using population, computational, functional data, and segregation data

There was some clinical improvement but the patient had a long standing severe encephalopathy

10.1016/j.jphs.2014.12.010 61 LiuT.YangL.GaoH.ZhuoY.TuZ.WangY.et al (2022)

In the future, with more extensive and in-depth research and clinical trials, it is hoped that natural medicines, including diet and herbs, will be more widely accepted, used alone or as adjuvant drugs for the treatment of RA