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doi: 10.1038/s41418-022-01074-0 104 HellmanN

[7] Rosenstock J, et al

Additionally, the significant correlations obtained between homocysteine levels and lipid peroxidation parameters suggest that, under our experimental conditions, the observed pro-oxidant effects truly depend on the elevation of circulating homocysteine (Durand et al, 1997a)

Remarkably PIRA-like disability accumulation was also observed in pediatric MS raising the possibility that an underlying degenerative process can start very early (De Stefano et al., 2010