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NAPQI is a reactive metabolite formed by the action of cytochrome P450 on paracetamol (acetaminophen)

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Figure 1 Tumor development and progression depend on the interactions between cancer cells and multiple cell types surrounding the tumor, constituting the tumor microenvironment (TME) ( This review summarizes the data obtained from various studies to explore the benefits of QUE in combination with various chemotherapeutic agents, which manifest in two aspects: enhanced chemotherapy sensitivity and reduced toxic side effects of chemotherapy

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