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In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

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Anti-inflammatory activity: Researchers report suppression of inflammatory signaling like NF-B, along with reductions in cytokines tied to redness, irritation, and tissue stress