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Results of preclinical and in vitro studies have shown that activation of the IRR requires concentrations of ARA 290 greater than or equal to ~1 nmol/L (~1.3 ng/mL) (14)

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Symptoms Associated with Hypermobile Ehlers-Danlos Syndrome Diagnostic Evaluation CLINICAL FEATURES The diagnosis of hypermobile EDS should be considered in patients with clinical features noted in Table 2