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Phase 2 trial (NEJM 2023) randomized 338 adults with obesity to retatrutide doses from 1 mg to 12 mg/week

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In line with these observations, induced degradation of endogenously Halo-tagged TRF1 reduced telomere association of overexpressed TIN2 and POT1 but not TRF2, which is proposed to form a separate subcomplex with RAP1 47

Researchers observed that dairy cows harboring a Bifidobacterium -dominated enterotype exhibited faster recovery following LPS challenge, with accelerated restoration of SCFAs, enhanced amino acid metabolism, improved glucose homeostasis, and higher milk fat and protein content compared to other enterotypes, suggesting that intrinsic microbiome configurations may determine host resilience to inflammatory challenges 94