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Mechanistically, kefiran (KE) and kefir exo-polysaccharides (KEPS), as well as KPs, inhibit key inflammatory signaling pathways including NF-B, p-MAPK, p-IkB, pp38, and p-JNK, thereby reducing epithelial cell activation, synovitis, macrophage-mediated inflammation, and cytokine overproduction in systemic and localized inflammatory conditions (Chuang et al., 2023