The role of Xanthine oxidoreductase and uric acid in metabolic syndrome
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An in vitro study revealed that AGEs binding to RAGE on macrophages and microglia promote oxidative stress by activating NF-KB, and MAPK, c-Jun N-terminal kinase (JNK), and p21RAS signaling pathways (197)
However, the results revealed that a total of 125 and 62 metabolites in the external and internal metabolome, respectively, had significant variations in the combination group (Figure 4)
